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Gleevec Increases Levels of the Amyloid Precursor Protein Intracellular Domain and of the Amyloid-β–degrading Enzyme Neprilysin

Amyloid-β (Aβ) deposition is a major pathological hallmark of Alzheimer's disease. Gleevec, a known tyrosine kinase inhibitor, has been shown to lower Aβ secretion, and it is considered a potential basis for novel therapies for Alzheimer's disease. Here, we show that Gleevec decreases Aβ l...

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Detaylı Bibliyografya
Asıl Yazarlar: Eisele, Yvonne S., Baumann, Matthias, Klebl, Bert, Nordhammer, Christina, Jucker, Mathias, Kilger, Ellen
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Cell Biology 2007
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC1951756/
https://ncbi.nlm.nih.gov/pubmed/17626163
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E07-01-0035
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