Regulatory feedback cycle of the insulin‐degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer’s disease

One of the major pathological hallmarks of Alzheimer´s disease (AD) is an accumulation of amyloid‐β (Aβ) in brain tissue leading to formation of toxic oligomers and senile plaques. Under physiological conditions, a tightly balanced equilibrium between Aβ‐production and ‐degradation is necessary to p...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:Aging Cell
मुख्य लेखकों: Lauer, Anna A., Mett, Janine, Janitschke, Daniel, Thiel, Andrea, Stahlmann, Christoph P., Bachmann, Cornel M., Ritzmann, Felix, Schrul, Bianca, Müller, Ulrike C., Stein, Reuven, Riemenschneider, Matthias, Grimm, Heike S., Hartmann, Tobias, Grimm, Marcus O. W.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: John Wiley and Sons Inc. 2020
विषय:
Original Articles
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681056/
https://ncbi.nlm.nih.gov/pubmed/33128835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13264
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