Regulatory feedback cycle of the insulin‐degrading enzyme and the amyloid precursor protein intracellular domain: Implications for Alzheimer’s disease

One of the major pathological hallmarks of Alzheimer´s disease (AD) is an accumulation of amyloid‐β (Aβ) in brain tissue leading to formation of toxic oligomers and senile plaques. Under physiological conditions, a tightly balanced equilibrium between Aβ‐production and ‐degradation is necessary to p...

Popoln opis

Shranjeno v:
Bibliografske podrobnosti
izdano v:Aging Cell
Main Authors: Lauer, Anna A., Mett, Janine, Janitschke, Daniel, Thiel, Andrea, Stahlmann, Christoph P., Bachmann, Cornel M., Ritzmann, Felix, Schrul, Bianca, Müller, Ulrike C., Stein, Reuven, Riemenschneider, Matthias, Grimm, Heike S., Hartmann, Tobias, Grimm, Marcus O. W.
Format: Artigo
Jezik:Inglês
Izdano: John Wiley and Sons Inc. 2020
Teme:
Original Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7681056/
https://ncbi.nlm.nih.gov/pubmed/33128835
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/acel.13264
Oznake: Označite
Brez oznak, prvi označite!

Podobne knjige/članki