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Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection
Engineered Cys(2)His(2) zinc finger proteins (ZFPs) can mediate regulation of endogenous gene expression in mammalian cells. Ideally, all zinc fingers in an engineered multifinger protein should be optimized concurrently because cooperative and context-dependent contacts can affect DNA recognition....
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2003
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC218748/ https://ncbi.nlm.nih.gov/pubmed/14527993 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.2135381100 |
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