Glucocorticoids Antagonize Ap-1 by Inhibiting the Activation/Phosphorylation of Jnk without Affecting Its Subcellular Distribution

The immunosuppressive and antiinflammatory actions of glucocorticoid hormones are mediated by their transrepression of activating protein-1 (AP-1) and nuclear factor-kappa B (NFκB) transcription factors. Inhibition of the c-Jun NH(2)-terminal kinase (JNK) signaling pathway, the main mediator of AP-1...

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Main Authors: González, María Victoria, Jiménez, Benilde, Berciano, María T., González-Sancho, José Manuel, Caelles, Carme, Lafarga, Miguel, Muñoz, Alberto
Formato: Artigo
Idioma:Inglês
Publicado: The Rockefeller University Press 2000
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2175250/
https://ncbi.nlm.nih.gov/pubmed/10974006
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