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IL-2 and IL-15 Each Mediate De Novo Induction of FOXP3 Expression in Human Tumor Antigen-specific CD8 T Cells

Although FOXP3 is primarily expressed by regulatory CD4 T cells (T(reg)) in vivo, polyclonal activation of human CD8 T cells can result in the expression of FOXP3 in a fraction of CD8 T cells. However, the cellular lineage and mechanism of FOXP3 induction in CD8 T cells remain unclear. Here, we demo...

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Detalhes bibliográficos
Main Authors: Ahmadzadeh, Mojgan, Antony, Paul A., Rosenberg, Steven A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174606/
https://ncbi.nlm.nih.gov/pubmed/17414320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/CJI.0b013e3180336787
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