HDAC inhibitor valproic acid upregulates CAR in vitro and in vivo

BACKGROUND: The presence of CAR in diverse tumor types is heterogeneous with implications in tumor transduction efficiency in the context of adenoviral mediated cancer gene therapy. Preliminary studies suggest that CAR transcriptional regulation is modulated through histone acetylation and not throu...

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Hlavní autoři: Segura-Pacheco, Blanca, Avalos, Berenice, Rangel, Edgar, Velazquez, Dora, Cabrera, Gustavo
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2007
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174455/
https://ncbi.nlm.nih.gov/pubmed/17892546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-0556-5-10
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