Synergistic Antitumor Effects of Novel HDAC Inhibitors and Paclitaxel In Vitro and In Vivo

Preclinical studies support the therapeutic potential of histone deacetylases inhibitors (HDACi) in combination with taxanes. The efficacy of combination has been mainly ascribed to a cooperative effect on microtubule stabilization following tubulin acetylation. In the present study we investigated...

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Detalhes bibliográficos
Main Authors: Zuco, Valentina, De Cesare, Michelandrea, Cincinelli, Raffaella, Nannei, Raffaella, Pisano, Claudio, Zaffaroni, Nadia, Zunino, Franco
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2011
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3241602/
https://ncbi.nlm.nih.gov/pubmed/22194993
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029085
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