Antineoplastic effects of the DNA methylation inhibitor hydralazine and the histone deacetylase inhibitor valproic acid in cancer cell lines

BACKGROUND: Among the epigenetic alterations occurring in cancer, DNA hypermethylation and histone hypoacetylation are the focus of intense research because their pharmacological inhibition has shown to produce antineoplastic activity in a variety of experimental models. The objective of this study...

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Autors principals: Chavez-Blanco, Alma, Perez-Plasencia, Carlos, Perez-Cardenas, Enrique, Carrasco-Legleu, Claudia, Rangel-Lopez, Edgar, Segura-Pacheco, Blanca, Taja-Chayeb, Lucia, Trejo-Becerril, Catalina, Gonzalez-Fierro, Aurora, Candelaria, Myrna, Cabrera, Gustavo, Duenas-Gonzalez, Alfonso
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2006
Matèries:
Primary Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC1408081/
https://ncbi.nlm.nih.gov/pubmed/16448574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1475-2867-6-2
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