Histone acetylation and histone deacetylase activity of magnesium valproate in tumor and peripheral blood of patients with cervical cancer. A phase I study

BACKGROUND: The development of cancer has been associated with epigenetic alterations such as aberrant histone deacetylase (HDAC) activity. It was recently reported that valproic acid is an effective inhibitor of histone deacetylases and as such induces tumor cell differentiation, apoptosis, or grow...

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Detalhes bibliográficos
Main Authors: Chavez-Blanco, Alma, Segura-Pacheco, Blanca, Perez-Cardenas, Enrique, Taja-Chayeb, Lucia, Cetina, Lucely, Candelaria, Myrna, Cantu, David, Gonzalez-Fierro, Aurora, Garcia-Lopez, Patricia, Zambrano, Pilar, Perez-Plasencia, Carlos, Cabrera, Gustavo, Trejo-Becerril, Catalina, Angeles, Enrique, Duenas-Gonzalez, Alfonso
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2005
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC1198251/
https://ncbi.nlm.nih.gov/pubmed/16001982
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1476-4598-4-22
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