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G protein–coupled receptor/arrestin3 modulation of the endocytic machinery

Nonvisual arrestins (arr) modulate G protein–coupled receptor (GPCR) desensitization and internalization and bind to both clathrin (CL) and AP-2 components of the endocytic coated pit (CP). This raises the possibility that endocytosis of some GPCRs may be a consequence of arr-induced de novo CP form...

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Autori principali: Santini, Francesca, Gaidarov, Ibragim, Keen, James H.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Rockefeller University Press 2002
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2174075/
https://ncbi.nlm.nih.gov/pubmed/11839771
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200110132
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