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A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65

The signals involved in axonal trafficking and presynaptic clustering are poorly defined. Here we show that targeting of the γ-aminobutyric acid–synthesizing enzyme glutamate decarboxylase 65 (GAD65) to presynaptic clusters is mediated by its palmitoylated 60-aa NH(2)-terminal domain and that this r...

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Detalhes bibliográficos
Main Authors: Kanaani, Jamil, El-Husseini, Alaa El-Din, Aguilera-Moreno, Andrea, Diacovo, Julia M., Bredt, David S., Baekkeskov, Steinunn
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2002
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173248/
https://ncbi.nlm.nih.gov/pubmed/12356867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200205053
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