Aberrant Accumulation of the Diabetes Autoantigen GAD65 in Golgi Membranes in Conditions of ER Stress and Autoimmunity

Pancreatic islet β-cells are particularly susceptible to endoplasmic reticulum (ER) stress, which is implicated in β-cell dysfunction and loss during the pathogenesis of type 1 diabetes (T1D). The peripheral membrane protein GAD65 is an autoantigen in human T1D. GAD65 synthesizes γ-aminobutyric acid...

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Detalhes bibliográficos
Publicado no:Diabetes
Main Authors: Phelps, Edward A., Cianciaruso, Chiara, Michael, Iacovos P., Pasquier, Miriella, Kanaani, Jamil, Nano, Rita, Lavallard, Vanessa, Billestrup, Nils, Hubbell, Jeffrey A., Baekkeskov, Steinunn
Formato: Artigo
Idioma:Inglês
Publicado em: American Diabetes Association 2016
Assuntos:
Islet Studies
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5001175/
https://ncbi.nlm.nih.gov/pubmed/27284108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db16-0180
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