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A combination of three distinct trafficking signals mediates axonal targeting and presynaptic clustering of GAD65

The signals involved in axonal trafficking and presynaptic clustering are poorly defined. Here we show that targeting of the γ-aminobutyric acid–synthesizing enzyme glutamate decarboxylase 65 (GAD65) to presynaptic clusters is mediated by its palmitoylated 60-aa NH(2)-terminal domain and that this r...

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Hlavní autoři: Kanaani, Jamil, El-Husseini, Alaa El-Din, Aguilera-Moreno, Andrea, Diacovo, Julia M., Bredt, David S., Baekkeskov, Steinunn
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2002
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2173248/
https://ncbi.nlm.nih.gov/pubmed/12356867
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200205053
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