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A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C

Signals transduced by kinases depend on the extent and duration of substrate phosphorylation. We generated genetically encoded fluorescent reporters for PKC activity that reversibly respond to stimuli activating PKC. Specifically, phosphorylation of the reporter expressed in mammalian cells causes c...

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Hlavní autoři: Violin, Jonathan D., Zhang, Jin, Tsien, Roger Y., Newton, Alexandra C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 2003
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172956/
https://ncbi.nlm.nih.gov/pubmed/12782683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200302125
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