Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity

Prosurvival Bcl-2–like proteins, like Bcl-w, are thought to function on organelles such as the mitochondrion and to be targeted to them by their hydrophobic COOH-terminal domain. We unexpectedly found, however, that the membrane association of Bcl-w was enhanced during apoptosis. In healthy cells, B...

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Hauptverfasser: Wilson-Annan, Julie, O'Reilly, Lorraine A., Crawford, Simon A., Hausmann, George, Beaumont, Jennifer G., Parma, Loes P., Chen, Lin, Lackmann, Martin, Lithgow, Trevor, Hinds, Mark G., Day, Catherine L., Adams, Jerry M., Huang, David C.S.
Format: Artigo
Sprache:Inglês
Veröffentlicht: The Rockefeller University Press 2003
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172834/
https://ncbi.nlm.nih.gov/pubmed/12952938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200302144
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