Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

VEGF is unique among angiogenic growth factors because it disrupts endothelial barrier function. Therefore, we considered whether this property of VEGF might contribute to tumor cell extravasation and metastasis. To test this, mice lacking the Src family kinases Src or Yes, which maintain endothelia...

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Autors principals: Weis, Sara, Cui, Jianhua, Barnes, Leo, Cheresh, David
Format: Artigo
Idioma:Inglês
Publicat: The Rockefeller University Press 2004
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172541/
https://ncbi.nlm.nih.gov/pubmed/15504909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200408130
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