Endothelial barrier disruption by VEGF-mediated Src activity potentiates tumor cell extravasation and metastasis

VEGF is unique among angiogenic growth factors because it disrupts endothelial barrier function. Therefore, we considered whether this property of VEGF might contribute to tumor cell extravasation and metastasis. To test this, mice lacking the Src family kinases Src or Yes, which maintain endothelia...

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Autores principales: Weis, Sara, Cui, Jianhua, Barnes, Leo, Cheresh, David
Formato: Artigo
Lenguaje:Inglês
Publicado: The Rockefeller University Press 2004
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Research Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172541/
https://ncbi.nlm.nih.gov/pubmed/15504909
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200408130
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