Terminal osteoblast differentiation, mediated by runx2 and p27(KIP1), is disrupted in osteosarcoma

The molecular basis for the inverse relationship between differentiation and tumorigenesis is unknown. The function of runx2, a master regulator of osteoblast differentiation belonging to the runt family of tumor suppressor genes, is consistently disrupted in osteosarcoma cell lines. Ectopic express...

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Detalhes bibliográficos
Main Authors: Thomas, David M., Johnson, Sandra A., Sims, Natalie A., Trivett, Melanie K., Slavin, John L., Rubin, Brian P., Waring, Paul, McArthur, Grant A., Walkley, Carl R., Holloway, Andrew J., Diyagama, Dileepa, Grim, Jonathon E., Clurman, Bruce E., Bowtell, David D.L., Lee, Jong-Seo, Gutierrez, Gabriel M., Piscopo, Denise M., Carty, Shannon A., Hinds, Philip W.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172443/
https://ncbi.nlm.nih.gov/pubmed/15583032
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200409187
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