A pathway of neuregulin-induced activation of cofilin-phosphatase Slingshot and cofilin in lamellipodia

Cofilin mediates lamellipodium extension and polarized cell migration by stimulating actin filament dynamics at the leading edge of migrating cells. Cofilin is inactivated by phosphorylation at Ser-3 and reactivated by cofilin-phosphatase Slingshot-1L (SSH1L). Little is known of signaling mechanisms...

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Main Authors: Nagata-Ohashi, Kyoko, Ohta, Yusaku, Goto, Kazumichi, Chiba, Shuhei, Mori, Reiko, Nishita, Michiru, Ohashi, Kazumasa, Kousaka, Kazuyoshi, Iwamatsu, Akihiro, Niwa, Ryusuke, Uemura, Tadashi, Mizuno, Kensaku
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2004
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172350/
https://ncbi.nlm.nih.gov/pubmed/15159416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200401136
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