Insulin Receptor Substrate-4 Binds to Slingshot-1 Phosphatase and Promotes Cofilin Dephosphorylation

Cofilin plays an essential role in cell migration and morphogenesis by enhancing actin filament dynamics via its actin filament-severing activity. Slingshot-1 (SSH1) is a protein phosphatase that plays a crucial role in regulating actin dynamics by dephosphorylating and reactivating cofilin. In this...

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Detalhes bibliográficos
Main Authors: Homma, Yuta, Kanno, Shin-ichiro, Sasaki, Kazutaka, Nishita, Michiru, Yasui, Akira, Asano, Tomoichiro, Ohashi, Kazumasa, Mizuno, Kensaku
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2014
Assuntos:
Signal Transduction
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4176240/
https://ncbi.nlm.nih.gov/pubmed/25100728
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.565945
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