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Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration
Cofilin mediates lamellipodium extension and polarized cell migration by accelerating actin filament dynamics at the leading edge of migrating cells. Cofilin is inactivated by LIM kinase (LIMK)–1-mediated phosphorylation and is reactivated by cofilin phosphatase Slingshot (SSH)-1L. In this study, we...
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| Autori principali: | , , , , , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
The Rockefeller University Press
2005
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2171197/ https://ncbi.nlm.nih.gov/pubmed/16230460 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200504029 |
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