Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration

Cofilin mediates lamellipodium extension and polarized cell migration by accelerating actin filament dynamics at the leading edge of migrating cells. Cofilin is inactivated by LIM kinase (LIMK)–1-mediated phosphorylation and is reactivated by cofilin phosphatase Slingshot (SSH)-1L. In this study, we...

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Detaylı Bibliyografya
Asıl Yazarlar: Nishita, Michiru, Tomizawa, Chinatsu, Yamamoto, Masahiro, Horita, Yuji, Ohashi, Kazumasa, Mizuno, Kensaku
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The Rockefeller University Press 2005
Konular:
Research Articles
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171197/
https://ncbi.nlm.nih.gov/pubmed/16230460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200504029
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