Spatial and temporal regulation of cofilin activity by LIM kinase and Slingshot is critical for directional cell migration

Cofilin mediates lamellipodium extension and polarized cell migration by accelerating actin filament dynamics at the leading edge of migrating cells. Cofilin is inactivated by LIM kinase (LIMK)–1-mediated phosphorylation and is reactivated by cofilin phosphatase Slingshot (SSH)-1L. In this study, we...

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Bibliographic Details
Main Authors: Nishita, Michiru, Tomizawa, Chinatsu, Yamamoto, Masahiro, Horita, Yuji, Ohashi, Kazumasa, Mizuno, Kensaku
Format: Artigo
Language:Inglês
Published: The Rockefeller University Press 2005
Subjects:
Research Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171197/
https://ncbi.nlm.nih.gov/pubmed/16230460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200504029
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