The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

Insulin-like growth factors elicit many responses through activation of phosphoinositide 3-OH kinase (PI3K). The tuberous sclerosis complex (TSC1-2) suppresses cell growth by negatively regulating a protein kinase, p70S6K (S6K1), which generally requires PI3K signals for its activation. Here, we sho...

Полное описание

Сохранить в:
Библиографические подробности
Главные авторы: Harrington, Laura S., Findlay, Greg M., Gray, Alex, Tolkacheva, Tatiana, Wigfield, Simon, Rebholz, Heike, Barnett, Jill, Leslie, Nick R., Cheng, Susan, Shepherd, Peter R., Gout, Ivan, Downes, C. Peter, Lamb, Richard F.
Формат: Artigo
Язык:Inglês
Опубликовано: The Rockefeller University Press 2004
Предметы:
Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172316/
https://ncbi.nlm.nih.gov/pubmed/15249583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200403069
Метки: Добавить метку
Нет меток, Требуется 1-ая метка записи!

Схожие документы