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TSC1 and TSC2 tumor suppressors antagonize insulin signaling in cell growth
Tuberous sclerosis is a human disease caused by mutations in the TSC1 or the TSC2 tumor suppressor gene. Previous studies of a Drosophila TSC2 homolog suggested a role for the TSC genes in maintaining DNA content, with loss of TSC2 leading to polyploidy and increased cell size. We have isolated muta...
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| Main Authors: | , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2001
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| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC312704/ https://ncbi.nlm.nih.gov/pubmed/11390358 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.901101 |
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