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Potential therapeutic targets for chordoma: PI3K/AKT/TSC1/TSC2/mTOR pathway

Chordomas are radio- and chemo-resistant tumours and metastasise in as many as 40% of patients. The aim of this study was to identify potential molecular targets for the treatment of chordoma. In view of the reported association of chordoma and tuberous sclerosis complex syndrome, and the available...

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Hlavní autoři: Presneau, N, Shalaby, A, Idowu, B, Gikas, P, Cannon, S R, Gout, I, Diss, T, Tirabosco, R, Flanagan, A M
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2009
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2694420/
https://ncbi.nlm.nih.gov/pubmed/19401700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605019
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