The TSC1-2 tumor suppressor controls insulin–PI3K signaling via regulation of IRS proteins

Insulin-like growth factors elicit many responses through activation of phosphoinositide 3-OH kinase (PI3K). The tuberous sclerosis complex (TSC1-2) suppresses cell growth by negatively regulating a protein kinase, p70S6K (S6K1), which generally requires PI3K signals for its activation. Here, we sho...

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Bibliografski detalji
Glavni autori: Harrington, Laura S., Findlay, Greg M., Gray, Alex, Tolkacheva, Tatiana, Wigfield, Simon, Rebholz, Heike, Barnett, Jill, Leslie, Nick R., Cheng, Susan, Shepherd, Peter R., Gout, Ivan, Downes, C. Peter, Lamb, Richard F.
Format: Artigo
Jezik:Inglês
Izdano: The Rockefeller University Press 2004
Teme:
Research Articles
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172316/
https://ncbi.nlm.nih.gov/pubmed/15249583
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200403069
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