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Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes
To investigate the degradation mechanism of misfolded membrane proteins from the cell surface, we used mutant cystic fibrosis transmembrane conductance regulators (CFTRs) exhibiting conformational defects in post-Golgi compartments. Here, we show that the folding state of CFTR determines the post-en...
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| Main Authors: | , , , , , , , , , , |
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| פורמט: | Artigo |
| שפה: | Inglês |
| יצא לאור: |
The Rockefeller University Press
2004
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| נושאים: | |
| גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172283/ https://ncbi.nlm.nih.gov/pubmed/15007060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200312018 |
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