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Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes
To investigate the degradation mechanism of misfolded membrane proteins from the cell surface, we used mutant cystic fibrosis transmembrane conductance regulators (CFTRs) exhibiting conformational defects in post-Golgi compartments. Here, we show that the folding state of CFTR determines the post-en...
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| Autors principals: | , , , , , , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
The Rockefeller University Press
2004
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2172283/ https://ncbi.nlm.nih.gov/pubmed/15007060 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200312018 |
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