Misfolding diverts CFTR from recycling to degradation: quality control at early endosomes

To investigate the degradation mechanism of misfolded membrane proteins from the cell surface, we used mutant cystic fibrosis transmembrane conductance regulators (CFTRs) exhibiting conformational defects in post-Golgi compartments. Here, we show that the folding state of CFTR determines the post-en...

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Detalhes bibliográficos
Main Authors: Sharma, Manu, Pampinella, Francesca, Nemes, Csilla, Benharouga, Mohamed, So, Jeffrey, Du, Kai, Bache, Kristi G., Papsin, Blake, Zerangue, Noa, Stenmark, Harald, Lukacs, Gergely L.
Formato: Artigo
Idioma:Inglês
Publicado em: The Rockefeller University Press 2004
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2172283/
https://ncbi.nlm.nih.gov/pubmed/15007060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200312018
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