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Amyloid-β peptide induces oligodendrocyte death by activating the neutral sphingomyelinase–ceramide pathway

Amyloid-β peptide (Aβ) accumulation in senile plaques, a pathological hallmark of Alzheimer's disease (AD), has been implicated in neuronal degeneration. We have recently demonstrated that Aβ induced oligodendrocyte (OLG) apoptosis, suggesting a role in white matter pathology in AD. Here, we ex...

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Bibliografiske detaljer
Main Authors: Lee, Jiunn-Tay, Xu, Jan, Lee, Jin-Moo, Ku, Grace, Han, Xianlin, Yang, Ding-I, Chen, Shawei, Hsu, Chung Y.
Format: Artigo
Sprog:Inglês
Udgivet: The Rockefeller University Press 2004
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2171973/
https://ncbi.nlm.nih.gov/pubmed/14709545
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1083/jcb.200307017
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