Peptidoglycan Induces Cyclooxygenase-2 Expression in Macrophages by Activating the Neutral Sphingomyelinase-Ceramide Pathway

The sphingomyelin signal transduction pathway is known to play a role in mediating the action of various cytokines. Herein, we examined the role of neutral sphingomyelinase (nSMase)/ceramide in peptidoglycan (PGN)-induced NF-κB activation and cyclooxygenase-2 (COX-2) expression in macrophages. PGN-i...

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Autori principali: Chen, Bing-Chang, Chang, Huey-Mei, Hsu, Ming-Jen, Shih, Chwen-Ming, Chiu, Yi-Hua, Chiu, Wen-Ta, Lin, Chien-Huang
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Biochemistry and Molecular Biology 2009
Soggetti:
Mechanisms of Signal Transduction
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2742821/
https://ncbi.nlm.nih.gov/pubmed/19531467
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.028084
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