Mammalian Sir2 Homolog SIRT3 Regulates Global Mitochondrial Lysine Acetylation

Homologs of the Saccharomyces cerevisiae Sir2 protein, sirtuins, promote longevity in many organisms. Studies of the sirtuin SIRT3 have so far been limited to cell culture systems. Here, we investigate the localization and function of SIRT3 in vivo. We show that endogenous mouse SIRT3 is a soluble m...

ver descrição completa

Na minha lista:
Detalhes bibliográficos
Main Authors: Lombard, David B., Alt, Frederick W., Cheng, Hwei-Ling, Bunkenborg, Jakob, Streeper, Ryan S., Mostoslavsky, Raul, Kim, Jennifer, Yancopoulos, George, Valenzuela, David, Murphy, Andrew, Yang, Yinhua, Chen, Yaohui, Hirschey, Matthew D., Bronson, Roderick T., Haigis, Marcia, Guarente, Leonard P., Farese, Robert V., Weissman, Sherman, Verdin, Eric, Schwer, Bjoern
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2169418/
https://ncbi.nlm.nih.gov/pubmed/17923681
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01636-07
Tags: Adicionar Tag
Sem tags, seja o primeiro a adicionar uma tag!

Registos relacionados