Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

SIRT1 is a mammalian homolog of the Saccharomyces cerevisiae chromatin silencing factor Sir2. Dominant-negative and overexpression studies have implicated a role for SIRT1 in deacetylating the p53 tumor suppressor protein to dampen apoptotic and cellular senescence pathways. To elucidate SIRT1 funct...

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Detalhes bibliográficos
Main Authors: Cheng, Hwei-Ling, Mostoslavsky, Raul, Saito, Shin'ichi, Manis, John P., Gu, Yansong, Patel, Parin, Bronson, Roderick, Appella, Ettore, Alt, Frederick W., Chua, Katrin F.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2003
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC196882/
https://ncbi.nlm.nih.gov/pubmed/12960381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1934713100
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