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Fiber Shaft-Chimeric Adenovirus Vectors Lacking the KKTK Motif Efficiently Infect Liver Cells In Vivo

The molecular mechanisms governing the infectivity of adenovirus (Ad) toward specific cell and tissue types in vivo remain poorly understood. The direct Ad binding to hepatic heparan sulfate proteoglycans via the KKTK motif within the fiber shaft domain was suggested to be the major mechanism of Ad...

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Detalhes bibliográficos
Main Authors: Di Paolo, Nelson C., Kalyuzhniy, Oleksandr, Shayakhmetov, Dmitry M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168974/
https://ncbi.nlm.nih.gov/pubmed/17855526
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01584-07
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