Analysis of Adenovirus Sequestration in the Liver, Transduction of Hepatic Cells, and Innate Toxicity after Injection of Fiber-Modified Vectors

After intravenous administration, adenovirus (Ad) vectors are predominantly sequestered by the liver. Delineating the mechanisms for Ad accumulation in the liver is crucial for a better understanding of Ad clearance and Ad-associated innate toxicity. To help address these issues, in this study, we u...

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Detalles Bibliográficos
Publicado en:J Virol
Autores principales: Shayakhmetov, Dmitry M., Li, Zong-Yi, Ni, Shaoheng, Lieber, André
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2004
Materias:
Gene Therapy
Acceso en línea:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC400378/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15113916/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.10.5368-5381.2004
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