Analysis of Adenovirus Sequestration in the Liver, Transduction of Hepatic Cells, and Innate Toxicity after Injection of Fiber-Modified Vectors

After intravenous administration, adenovirus (Ad) vectors are predominantly sequestered by the liver. Delineating the mechanisms for Ad accumulation in the liver is crucial for a better understanding of Ad clearance and Ad-associated innate toxicity. To help address these issues, in this study, we u...

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Bibliografiska uppgifter
Huvudupphovsmän: Shayakhmetov, Dmitry M., Li, Zong-Yi, Ni, Shaoheng, Lieber, André
Materialtyp: Artigo
Språk:Inglês
Publicerad: American Society for Microbiology 2004
Ämnen:
Gene Therapy
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC400378/
https://ncbi.nlm.nih.gov/pubmed/15113916
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.78.10.5368-5381.2004
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