Analysis of Adenovirus Sequestration in the Liver, Transduction of Hepatic Cells, and Innate Toxicity after Injection of Fiber-Modified Vectors

After intravenous administration, adenovirus (Ad) vectors are predominantly sequestered by the liver. Delineating the mechanisms for Ad accumulation in the liver is crucial for a better understanding of Ad clearance and Ad-associated innate toxicity. To help address these issues, in this study, we u...

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הוצא לאור ב:	J Virol
Principais autores:	Shayakhmetov, Dmitry M., Li, Zong-Yi, Ni, Shaoheng, Lieber, André
פורמט:	Artigo
שפה:	Inglês
יצא לאור:	American Society for Microbiology (ASM) 2004
נושאים:	Gene Therapy
גישה מקוונת:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC400378/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/15113916/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JVI.78.10.5368-5381.2004
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