A High-Capacity, Capsid-Modified Hybrid Adenovirus/Adeno-Associated Virus Vector for Stable Transduction of Human Hematopoietic Cells

To achieve stable gene transfer into human hematopoietic cells, we constructed a new vector, ΔAd5/35.AAV. This vector has a chimeric capsid containing adenovirus type 35 fibers, which conferred efficient infection of human hematopoietic cells. The ΔAd5/35.AAV vector genome is deleted for all viral g...

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Detalhes bibliográficos
Main Authors: Shayakhmetov, Dmitry M., Carlson, Cheryl A., Stecher, Hartmut, Li, Qiliang, Stamatoyannopoulos, George, Lieber, André
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2002
Assuntos:
Gene Therapy
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC135810/
https://ncbi.nlm.nih.gov/pubmed/11773389
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.76.3.1135-1143.2002
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