In Vitro and In Vivo Properties of Adenovirus Vectors with Increased Affinity to CD46

Gene transfer vectors containing adenovirus (Ad) serotype 35 (Ad35) fibers have shown promise for cancer and stem cell gene therapy. In this study, we attempted to improve the in vitro and in vivo infection properties of these vectors by increasing their affinity to the Ad35 fiber receptor CD46. We...

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Bibliographische Detailangaben
Hauptverfasser: Wang, Hongjie, Liu, Ying, Li, ZongYi, Tuve, Sebastian, Stone, Daniel, Kalyushniy, Oleksandr, Shayakhmetov, Dmitry, Verlinde, Christophe L. M., Stehle, Thilo, McVey, John, Baker, Andrew, Peng, Kah-Whye, Roffler, Steve, Lieber, André
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2008
Schlagworte:
Gene Delivery
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2573189/
https://ncbi.nlm.nih.gov/pubmed/18753195
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01308-08
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