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Antibody-Independent, CD4(+) T-Cell-Dependent Protection against Pneumococcal Colonization Elicited by Intranasal Immunization with Purified Pneumococcal Proteins

Immunity to pneumococcal colonization in mice by exposure to live or killed pneumococci has been shown to be antibody independent but dependent on CD4(+) T cells. Here we show that intranasal immunization with pneumococcal proteins (pneumococcal surface protein C, adhesin A, and a pneumolysoid) can...

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Main Authors: Basset, Alan, Thompson, Claudette M., Hollingshead, Susan K., Briles, David E., Ades, Edwin W., Lipsitch, Marc, Malley, Richard
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2007
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168310/
https://ncbi.nlm.nih.gov/pubmed/17698570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00773-07
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