Antibody-Independent, CD4(+) T-Cell-Dependent Protection against Pneumococcal Colonization Elicited by Intranasal Immunization with Purified Pneumococcal Proteins

Immunity to pneumococcal colonization in mice by exposure to live or killed pneumococci has been shown to be antibody independent but dependent on CD4(+) T cells. Here we show that intranasal immunization with pneumococcal proteins (pneumococcal surface protein C, adhesin A, and a pneumolysoid) can...

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Bibliographische Detailangaben
Hauptverfasser: Basset, Alan, Thompson, Claudette M., Hollingshead, Susan K., Briles, David E., Ades, Edwin W., Lipsitch, Marc, Malley, Richard
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2007
Schlagworte:
Microbial Immunity and Vaccines
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168310/
https://ncbi.nlm.nih.gov/pubmed/17698570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00773-07
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