Antibody-Independent, CD4(+) T-Cell-Dependent Protection against Pneumococcal Colonization Elicited by Intranasal Immunization with Purified Pneumococcal Proteins

Immunity to pneumococcal colonization in mice by exposure to live or killed pneumococci has been shown to be antibody independent but dependent on CD4(+) T cells. Here we show that intranasal immunization with pneumococcal proteins (pneumococcal surface protein C, adhesin A, and a pneumolysoid) can...

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Autores principales: Basset, Alan, Thompson, Claudette M., Hollingshead, Susan K., Briles, David E., Ades, Edwin W., Lipsitch, Marc, Malley, Richard
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology (ASM) 2007
Materias:
Microbial Immunity and Vaccines
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168310/
https://ncbi.nlm.nih.gov/pubmed/17698570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00773-07
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