Antibody-Independent, CD4(+) T-Cell-Dependent Protection against Pneumococcal Colonization Elicited by Intranasal Immunization with Purified Pneumococcal Proteins

Immunity to pneumococcal colonization in mice by exposure to live or killed pneumococci has been shown to be antibody independent but dependent on CD4(+) T cells. Here we show that intranasal immunization with pneumococcal proteins (pneumococcal surface protein C, adhesin A, and a pneumolysoid) can...

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Detalhes bibliográficos
Main Authors: Basset, Alan, Thompson, Claudette M., Hollingshead, Susan K., Briles, David E., Ades, Edwin W., Lipsitch, Marc, Malley, Richard
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2007
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2168310/
https://ncbi.nlm.nih.gov/pubmed/17698570
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00773-07
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