Molecular dynamics study displays near in-line attack conformations in the hammerhead ribozyme self-cleavage reaction
We have performed molecular dynamics (MD) calculations by using one of the recently solved crystal structures of a hammerhead ribozyme. By rotating the α, β, γ, δ, ɛ, and ζ torsion angles of the phosphate linkage of residue 17, the nucleobase at the cleavage site was slightly rotated out of the acti...
Uloženo v:
| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1998
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC21598/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/9736692/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.95.19.11077 |
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