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Molecular dynamics study displays near in-line attack conformations in the hammerhead ribozyme self-cleavage reaction

We have performed molecular dynamics (MD) calculations by using one of the recently solved crystal structures of a hammerhead ribozyme. By rotating the α, β, γ, δ, ɛ, and ζ torsion angles of the phosphate linkage of residue 17, the nucleobase at the cleavage site was slightly rotated out of the acti...

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Hlavní autoři: Torres, Rhonda A., Bruice, Thomas C.
Médium: Artigo
Jazyk:Inglês
Vydáno: The National Academy of Sciences 1998
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC21598/
https://ncbi.nlm.nih.gov/pubmed/9736692
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