The vanilloid receptor TRPV1 is activated and sensitized by local anesthetics in rodent sensory neurons

Local anesthetics (LAs) block the generation and propagation of action potentials by interacting with specific sites of voltage-gated Na(+) channels. LAs can also excite sensory neurons and be neurotoxic through mechanisms that are as yet undefined. Nonspecific cation channels of the transient recep...

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Bibliografiske detaljer
Main Authors: Leffler, Andreas, Fischer, Michael J., Rehner, Dietlinde, Kienel, Stephanie, Kistner, Katrin, Sauer, Susanne K., Gavva, Narender R., Reeh, Peter W., Nau, Carla
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Clinical Investigation 2008
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2157564/
https://ncbi.nlm.nih.gov/pubmed/18172555
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI32751
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