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Negative Charges at Protein Kinase C Sites of Troponin I Stabilize the Inactive State of Actin
Alterations in the troponin complex can lead to increases or decreases in contractile activity. Most mutations of troponin that cause hypertrophic cardiomyopathy increase the activity of cardiac muscle fibers. In at least some cases these mutants stabilize the active state of regulated actin. In con...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Biophysical Society
2008
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2157249/ https://ncbi.nlm.nih.gov/pubmed/17872964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.113944 |
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