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Negative Charges at Protein Kinase C Sites of Troponin I Stabilize the Inactive State of Actin

Alterations in the troponin complex can lead to increases or decreases in contractile activity. Most mutations of troponin that cause hypertrophic cardiomyopathy increase the activity of cardiac muscle fibers. In at least some cases these mutants stabilize the active state of regulated actin. In con...

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Bibliografiset tiedot
Päätekijät: Mathur, Mohit C., Kobayashi, Tomoyoshi, Chalovich, Joseph M.
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: The Biophysical Society 2008
Aiheet:
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC2157249/
https://ncbi.nlm.nih.gov/pubmed/17872964
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.113944
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