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Negative Charges at Protein Kinase C Sites of Troponin I Stabilize the Inactive State of Actin
Alterations in the troponin complex can lead to increases or decreases in contractile activity. Most mutations of troponin that cause hypertrophic cardiomyopathy increase the activity of cardiac muscle fibers. In at least some cases these mutants stabilize the active state of regulated actin. In con...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The Biophysical Society
2008
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2157249/ https://ncbi.nlm.nih.gov/pubmed/17872964 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1529/biophysj.107.113944 |
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