Transgenic Gαq overexpression induces cardiac contractile failure in mice

The critical cell signals that trigger cardiac hypertrophy and regulate the transition to heart failure are not known. To determine the role of Gαq-mediated signaling pathways in these events, transgenic mice were constructed that overexpressed wild-type Gαq in the heart using the α-myosin heavy cha...

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Detalhes bibliográficos
Main Authors: D’Angelo, Drew D., Sakata, Yoshihito, Lorenz, John N., Boivin, Gregory P., Walsh, Richard A., Liggett, Stephen B., Dorn, Gerald W.
Formato: Artigo
Idioma:Inglês
Publicado em: The National Academy of Sciences of the USA 1997
Assuntos:
Biological Sciences
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC21567/
https://ncbi.nlm.nih.gov/pubmed/9223325
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