Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory

Subcortical dopamine D2 receptor (DRD2) signaling is implicated in cognitive processes and brain disorders, but the effect of DRD2 variants remains ambiguous. We measured allelic mRNA expression in postmortem human striatum and prefrontal cortex and then performed single nucleotide polymorphism (SNP...

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Main Authors: Zhang, Ying, Bertolino, Alessandro, Fazio, Leonardo, Blasi, Giuseppe, Rampino, Antonio, Romano, Raffaella, Lee, Mei-Ling T., Xiao, Tao, Papp, Audrey, Wang, Danxin, Sadée, Wolfgang
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2007
Teme:
Biological Sciences
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2154469/
https://ncbi.nlm.nih.gov/pubmed/18077373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0707106104
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