Functional variants of the dopamine receptor D2 gene modulate prefronto-striatal phenotypes in schizophrenia

Dopamine D2 receptor signalling is strongly implicated in the aetiology of schizophrenia. We have recently characterized the function of three DRD2 SNPs: rs12364283 in the promoter affecting total D2 mRNA expression; rs2283265 and rs1076560, respectively in introns 5 and 6, shifting mRNA splicing to...

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Détails bibliographiques
Auteurs principaux: Bertolino, Alessandro, Fazio, Leonardo, Caforio, Grazia, Blasi, Giuseppe, Rampino, Antonio, Romano, Raffaella, Di Giorgio, Annabella, Taurisano, Paolo, Papp, Audrey, Pinsonneault, Julia, Wang, Danxin, Nardini, Marcello, Popolizio, Teresa, Sadee, Wolfgang
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2009
Sujets:
Original Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640212/
https://ncbi.nlm.nih.gov/pubmed/18829695
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/brain/awn248
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