Intronic Polymorphisms Affecting Alternative Splicing of Human Dopamine D2 Receptor Are Associated with Cocaine Abuse

The dopamine receptor D2 (encoded by DRD2) is implicated in susceptibility to mental disorders and cocaine abuse, but mechanisms responsible for this relationship remain uncertain. DRD2 mRNA exists in two main splice isoforms with distinct functions: D2 long (D2L) and D2 short (D2S, lacking exon 6),...

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Detalhes bibliográficos
Main Authors: Moyer, Robert A, Wang, Danxin, Papp, Audrey C, Smith, Ryan M, Duque, Linda, Mash, Deborah C, Sadee, Wolfgang
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3055737/
https://ncbi.nlm.nih.gov/pubmed/21150907
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/npp.2010.208
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